Have you checked the troubleshooting tips on the Logitech quick start guide?

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Microsoft Unifying Software

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Help with setup: Mouse is not working
1. Is the mouse powered on?
2. Is the Unifying receiver securely plugged into a computer USB port? Try changing USB ports.
3. If the Unifying receiver is plugged into a USB hub, try plugging it directly into a USB port on your computer.
4. Check the orientation of the batteries inside the mouse. To check battery power, turn the mouse OFF and then ON. If the battery indicator light glows red or does not glow at all, replace the batteries.
5. Try using the mouse on a different surface. Remove metallic objects between the mouse and the Unifying receiver.
6. Try moving the Unifying receiver to a USB port closer to the mouse. If you are using a tower PC, go to www.logitech.com/usbextenderfor a USB extender.
7. Try reconnecting the mouse and Unifying receiver using the Logitech Unifying software (refer to the

Unifying section of this guide

The Logitech® Unifying receiver
Plug it. Forget it. Add to it.Your new Logitech product ships with a Logitech® Unifying receiver.
Did you know you can add a compatible Logitech wireless device that uses the same receiver as your current Logitech Unifying product?

No Unifying Software For Mac Windows 7

Are you Unifying-ready?If you have a Logitech wireless device that’s Unifying-ready, you can pair it with additional Unifying devices. Just look for the orange Unifying logo on the new device or its packaging. Build your ideal combo. Add something. Replace something. It’s easy, and you’ll use only one USB port for up to six devices. Getting started is easyIf you’re ready to pair your device(s) via Unifying, here’s what you need to do:

Start Programs Logitech Unifying Logitech Unifying Software

1. Make sure your Unifying receiver is plugged in.
2. If you haven’t already, download the Logitech® Unifying software from www.logitech.com/unifying.
3. Start the Unifying software* and follow the onscreen instructions to pair the new wireless device with your existing Unifying receiver. * Go to Start / All Programs / Logitech / Unifying / Logitech Unifying Softwar